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Congenital heart disease

Pulmonary Valve Insufficiency (PI) as the name suggests is the malfunctioning of the pulmonary valve (PV).  It is one of the long-term sequelae of surgical procedure to rectify  Tetralogy of Fallot (TOF).  TOF, also called blue-baby syndrome, is one of the most common congenital heart defects in children after infancy and is estimated to account for 10% of all congenital heart defects.  TOF consists of four interrelated defects:  i) Ventricular septal defect (VSD) which is the hole between right and the left ventricle, ii) Pulmonary stenosis which is the result of the stiffening of the pulmonary arteries, iii) Right ventricular hypertrophy which results in enlarged right ventricle as it takes the mail function to pump blood and (iv) Overriding Aorta, as the aorta is almost connected to right ventricle.

Tetralogy of Fallot, has been successfully repaired for several decades and here are now an estimated 100,000 adult “repaired TOF” patients in the United States alone. As a result, long-term sequels of the disease and repair have become important clinical issue. Specifically, residual pulmonary valve insufficiency is one such accepted and often unavoidable sequel. Chronic pulmonary valve insufficiency (PI), when severe, abnormally alters the RV loading conditions, thereby triggering RV hypertrophy and dilatation. In turn, RV dilatation can evolve into irreversible RV myocardial contractile dysfunction, and has been related to sudden death in many “repaired TOF” patients. To normalize RV loading conditions, pulmonary valve replacement is often necessary and should be performed prior to the onset of irreversible RV myocardial damage.   


In this study we try to understand the performance of the right ventricle of the heart and the pulmonary arterial blood flow using Computational Fluid Dynamics and Fluid Structure Interactions study on patient specific data.




 MRI contours of Right Ventricle



by mkrishna — last modified 2015-05-26 11:17